We all know that smoking is bad for our health. However, do you know that research has proven that it also impacts on your coagulation system, and therefore on hemostasis and balance of your body? We know that smoking has a very visible effect on your skin. Perhaps not when you are in your twenties, but look at women particularly who have been smoking for ten years of longer. Unfortuanately, smoking impacts greatly on your platelets and fibrin networks. Researchers that have shown the impact of smoking on the coagulation system include:
Erhardt et al., in the journal Artherosclerosis, 2009; 205: 23-32
In research conducted by my research team at the University of Pretoria in 2010, we looked at how smoking affects the fibrin networks of healthy individuals who smoke (under ethical clearance). We drew blood from these individuals and sentrifuged the sample (this means we spinned the blood very vast in a machine called a centrifuge). We obtained plasma, which is the watery part of the blood.In the plasma, we find the plasma proteins and platelets that play a role in normal coagulation. In the body, if the coagulation cascade is triggered by e.g. damage to a small vessel inside the body, fibrin fibers will form. This is a natural process that will occur in all healthy individuals. In the body this network formations is facilitated by a special protein called thrombin. If we add thrombin to the plasma in the lab, we will mimic this fibrin creation process that will spontanously happen in the body when we have a small injury to e.g. a blood vessel. Therefore, if we add thrombin to the blood of a smoker, we can see how the smokers coagulation process via the fibrin networks, will look like. We use an electron microscope to view the fibers, as it is a very powerful instrument that can magnify up to a million times!
We found something very interesting when looking at the fibrin fibers of smokers. Their fibers seem to be sticking together and we coined a term: sticky fiber phenomenon when you smoke. What does this mean to your health? When you smoke, the toxins that you take in, affects the proteins in your plasma, and when you have a small injury e.g. in a blood vessel, you will form abnormally sticky fibrin networks. You may even perhaps spontanously form these thickened nets in your circulating blood. These thickened nets may struggle to break down by the normal process called lyses. If these thickened masses break loose it may cause you to have stroke or thrombosis. Unfortuanately, it is well-known that smoking causes stroke and thrombosis. This research was published in the journal Ultrastructural Pathology in 201o by Pretorius and co workers.
See the electron microscopy photo of a sticky fiber mass generated from the plasma of a smoker.